When Pope Leo XIV presented a 42,300-word open letter to the world’s 1.4 billion Catholics on Monday, calling for protections against the rise of artificial intelligence, he was joined by Christopher Olah, a co-founder of Anthropic, which is one of the tech industry’s leading A.I. companies.

As Leo urged corporate executives, government regulators and other citizens of the world to safeguard humanity from the dangers of A.I., he included Mr. Olah as a symbol of the dialogue he hopes to foster between the leaders of the spiritual and technological worlds.

But for Jeremy Nixon, Monday’s gathering at the Vatican showed that those two worlds are far from aligned. While the pope said that A.I. was fundamentally not human, Mr. Nixon, a well-connected figure in the Bay Area’s frenetic A.I. scene, argued that Mr. Olah’s remarks seemed to hint at the opposite.

“They are not in dialogue,” Mr. Nixon said during an interview at A.G.I. House, a San Francisco “hacker house” with deep ties to many of the people who helped create the A.I. technologies discussed in the pope’s encyclical. “Their perspectives are distinct.”

The difference between the humanist’s view of A.I.’s risks and the technologist’s dream of what it could become is something that has long been discussed in Mr. Nixon’s community. “It is the reason the community exists,” Mr. Nixon said. “It is its underlying purpose.”

Mr. Nixon, 33, is one of the founders of A.G.I. House, which is named for Silicon Valley’s headlong pursuit of “artificial general intelligence,” a hypothetical machine that can do anything the human brain can do.