Pope Leo XIV has been a major global critic of immigration crackdowns and war, staking out a moral agenda that has at times challenged the political leadership of his home country.

Now Leo, the first pope from the United States, has added to that list artificial intelligence, taking on American power brokers of another kind — this time in Silicon Valley.

Leo’s papal document, titled “Magnifica Humanitas,” or “Magnificent Humanity,” and made public on Monday, is the defining theological statement so far of his young papacy, and the most significant moral intervention on A.I. to date from a religious leader. It also is an effort to inject Catholic moral values into a famously secular, and significantly American, industry that is transforming the world at lightning speed.

“Crucial questions impose themselves on our conscience and can no longer be avoided: Where are we going? Toward what goal do we wish to orient ourselves? What direction should we choose as a people and as a human community?” Leo wrote.

Leo specifically called for A.I. to be “disarmed,” similar to the church’s support for nuclear disarmament, meaning “freed from logics that turn it into an instrument of domination, exclusion and death,” he explained in a speech at the Vatican.

The document’s release in the synod hall was styled as a branded launch event, with bright yellow banners and a splashy introductory video, produced with EWTN, an American Catholic network with global reach.